Prodromal symptoms may be identified by people with bipolar or unipolar depression

Prodromal symptoms may be identified by people with bipolar or unipolar depression.

Cortical folding in patients with bipolar disorder or unipolar depression.

BACKGROUND Analysis of cortical folding may provide insight into neurodevelopment deviations, which, in turn, can predispose to depression that responds particularly poorly to medications. We hypothesized that patients with treatment-resistant depression would exhibit measurable alterations in cortical folding. METHODS We computed hemispheric global sulcal indices (g-SIs) in T(1)-weighted mag...

Bipolar and unipolar depression.

Since Kraepelin grouped affective disorders under the title of 'manic-depressive insanity', there has been controversy over whether the bipolar and unipolar entities within this are distinct affective disorders or whether they are merely two ends of an affective continuum. In order to bring some clarity and goal-posts to this argument, we define the criteria that must be fulfilled by diseases i...

Detection of prodromal symptoms of relapse in mania & unipolar depression by relatives & patients

BACKGROUND & OBJECTIVES Detection of prodromal symptoms among patients with mania by their immediate relatives has been seldom examined. We carried out this study to examine the ability to detect and report prodromol symptoms of manic relapses by patients themselves and their relatives. METHODS The ability of patients and their relatives to detect prodromal symptoms was examined among 60 remi...

Conversion from unipolar depression to bipolar depression

BACKGROUND Clinicians, both psychiatrists and non-psychiatrists, underdiagnose bipolar disorder in a substantial proportion of depressed patients. Correct diagnosis is important since the prescription of antidepressants without mood stabilizers may precipitate a switch to mania. In patients presenting with depression, what are the odds they will turn out to really be bipolar? There are few long...